Piperacillin–tazobactam-associated thrombocytopenia with negative antiplatelet antibody testing: a case report and literature review

This case and the reviewed literature highlight that negative platelet antibody testing does not exclude piperacillin-tazobactam-associated DIIT. A structured diagnostic approach and close platelet monitoring are warranted when DIIT is suspected in critically ill patients. Clinical evaluation and temporal association remain critical for diagnosis.