Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

20260 citationsJournal Articlegold Open Access

Authors

Paulina Gonzalez‐Latapi · Kendall College

Caroline Gochanour · University of Iowa

Seung Ho Choi · University of Iowa

H. A. Cho · University of California San Diego

Chelsea Caspell‐Garcia · University of Iowa

Christopher Coffey · University of Iowa

Michael C. Brumm ·

Abstract

This study highlights the heterogeneity in the early Parkinson's Disease population defined by clinical diagnostic criteria and underscores the importance of shifting from clinical to biologically and functional impairment defined inclusion criteria for clinical trials. Biological drivers of stage heterogeneity must be further explored.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Voice and Speech Disorders

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Annals of Clinical and Translational Neurology

DOI: 10.1002/acn3.70323

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