Inosine alleviates colorectal cancer liver metastasis by promoting M1 macrophage polarization and modulating the PI3K/AKT signaling pathway

20260 citationsJournal Articlegold Open Access

Authors

Yadan Dong · Dali University

Yuchen Ma · Dali University

Q M Yu · Dali University

Zhengmei Shi · Dali University

Caiyi Wang · Dali University

Yi-Hao Che · Dali University

Heng Liu · Dali University

Abstract

Inosine exerted an inhibitory effect on colorectal cancer liver metastasis by skewing macrophages toward an M1 phenotype, dampening pro-inflammatory cytokine release, and regulating key genes via the PI3K/AKT pathway.

Topics & Keywords

Adenosine and Purinergic Signaling RNA regulation and disease Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 17, pp. 1780972-1780972

DOI: 10.3389/fimmu.2026.1780972

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