P02.09 CSF1R <sup>+</sup> myeloid cells mediate resistance to CAR-T-cell therapy in lung cancer brain metastases

20260 citationsJournal Articlebronze Open Access

Authors

Jens Blobner · Ludwig-Maximilians-Universität München

T Xu · Ludwig-Maximilians-Universität München

Jiahui Ji · LMU Klinikum

J Yang · Ludwig-Maximilians-Universität München

Alexander Beck · Ludwig-Maximilians-Universität München

Laura M. Bartos · Ludwig-Maximilians-Universität München

Julika J Herold

Abstract

Conclusion hAB serum is a highly complex component that provides various nutrient sources during CAR T cell manufacturing.While reducing its availability results in comparable culture properties, sc-sequencing identified DEG related to metabolism.However, the SCENITH protocol and mitochondrial mass did not support changes in translational and energy metabolism.Yet, other metabolism pathways remain to be tested to better understand the effect of hAB serum.

Topics & Keywords

Immune cells in cancer CAR-T cell therapy research Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Poster presentations

DOI: 10.1136/jitc-2026-itoc.23

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