Whole-Blood vs Component Therapy in Adult Trauma

20261 citationsJournal Articlegreen Open Access

Authors

Wesam Ibrahim · Tanta University

Kenneth Meza Monge · University of Colorado Anschutz Medical Campus

J Menzel · University of Colorado Anschutz Medical Campus

Luis Morales Ojeda · University of Colorado Anschutz Medical Campus

Michael Dalton · University of Colorado Anschutz Medical Campus

Daniel Alejandro Fuenmayor Lozada · University of Carabobo

Andrea Vidal-Gallardo

Abstract

In this updated systematic review and meta-analysis, whole-blood transfusion was associated with reduced mortality in civilian but not military adult trauma patients, although the wide 95% PIs suggest substantial heterogeneity, indicating that benefits may vary considerably across settings. These findings support selective whole-blood transfusion protocol implementation in civilian centers while highlighting the need for refined patient selection criteria.

Topics & Keywords

Trauma, Hemostasis, Coagulopathy, Resuscitation Trauma and Emergency Care Studies Blood transfusion and management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Surgery

DOI: 10.1001/jamasurg.2026.0197

Field-Weighted Citation Impact: 50.58