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Abstract: Microbial resistance or antimicrobial resistance (AMR) emerged as one of the greatest global health issues of the 21st century, originating from excessive use of antimicrobials. Tackling AMR requires careful and sustainable use of antimicrobials to effectively deal with the health issues it creates. Primary strategies to tackle AMR target precise diagnostics and rational prescribing practices using advanced infection treatment protocols, such as antimicrobial stewardship (AMS). At the same time, technologically advanced diagnostic procedures and biomarker development enable accurate pathogen detection, allowing for more target-oriented outcomes. Alternatively, probiotics, phage therapy, and antimicrobial peptides work as the greatest supporting pillars in the fight against AMR. Vaccination represents a promising advancement in public health, serving as a preventive approach that significantly lowers the need for antibiotics in both human and veterinary practice. From a regulatory perspective, controlling the misuse of antimicrobials is a critical step in safeguarding community health. This includes the complete restriction of over-the-counter antibiotic sales and the prohibition of non-therapeutic antibiotic use across all sectors of society. In addition, environmental strategies, such as reducing antibiotic pollution and improving wastewater treatment, further support sustainable AMR management. Public awareness campaigns and professional training initiatives highlight the importance of responsible antibiotic use; ultimately, the management of AMR requires multifaceted approaches, combining scientific innovation, policy enhancement, and global collaboration. Integrating AMR strategies into the United Nations Sustainable Development Goals (SDGs) can further enhance global efforts towards a healthier and more sustainable future.