Exosomes From Cancer‐Associated Fibroblasts Promote Colorectal Cancer Progression and Glutamine Metabolism Through METTL1‐Mediated m7G Modification of SLC1A5 mRNA

20260 citationsJournal Article

Authors

S. X. Zhang · Fujian Medical University

zhihua chen · Fujian Medical University

Chenyang Ma · Fujian Medical University

Jia Hu · Fujian Medical University

Suyong Lin · Fujian Medical University

Ji Gao · Fujian Medical University

Shaoqin Chen ·

Abstract

Our findings identify a novel CAFs-Exo/METTL1/SLC1A5 axis that drives CRC progression partially by reprogramming glutamine metabolism, revealing new potential therapeutic targets for CRC treatment.

Topics & Keywords

RNA modifications and cancer Cancer-related molecular mechanisms research RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Gastroenterology and Hepatology

DOI: 10.1111/jgh.70334

Field-Weighted Citation Impact: 0.00