High Intrahepatic cccDNA in Resolved HBV Infection: Insights From Living Donor Liver Transplantation With Anti‐HBc‐Positive Grafts

20260 citationsJournal Articlehybrid Open Access

Authors

Sung Kwan Bae · V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

Nobuhisa Akamatsu · V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

Akihiko Ichida · V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

Yujiro Nishioka · V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

Yoshinori Inagaki · Yokohama University of Pharmacy

Nozomi Miyake · Okayama University

Abstract

Even among patients with resolved HBV infection, there are cases possessing intrahepatic cccDNA levels as high as or even higher than those in HBsAg-positive patients. To resolve this critical pitfall in immunosuppressed patients, the development of serum markers that precisely reflect intrahepatic cccDNA levels will be essential for improving HBV prophylaxis strategies.

Topics & Keywords

Hepatitis B Virus Studies Organ Transplantation Techniques and Outcomes Liver physiology and pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Gastroenterology and Hepatology

DOI: 10.1111/jgh.70324

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