Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended

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Authors

Yicheng Ma · Shandong Provincial Hospital

Junming Han · Shandong Provincial Hospital

Qihang Li · Shandong Provincial Hospital

Xiao Jiang · Shandong Provincial Hospital

Yuan Li · Shandong Provincial Hospital

Keke Zhang · Shandong Provincial Hospital

Ling Gao ·

Abstract

The impact of per standard deviation (SD) decrease in sex hormone levels on aging (BAA) varies by age, with significant effects observed in females aged 50-55 years and males aged 65-70 years. These findings may facilitate the optimization of HRT timing to maximize anti-aging benefits and enable personalized treatment strategies.

Topics & Keywords

Hormonal and reproductive studies Menopause: Health Impacts and Treatments Sexual function and dysfunction studies

Publication Details

Published in: Biology of Sex Differences

DOI: 10.1186/s13293-026-00873-1

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Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended

Authors

Abstract

Topics & Keywords

Publication Details