Glymphatic dysfunction is associated with cognitive impairment in white matter hyperintensities: A DTI-based study

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Authors

Baogen Du · Anhui Medical University

Weiqiang Li · Anhui Medical University

Xin Wang · Anhui Medical University

Shihao Ruan · Anhui Medical University

Wenchen Sun · Anhui Medical University

Yuanyuan Liu · Wuhan Wudong Hospital

Shanshan Cao ·

Abstract

Cognitive impairment in patients with WMHs is closely linked to decreased DTI-ALPS index, especially as white matter lesions worsen. Glymphatic dysfunction may play a critical role in this cognitive impairment, positioning the DTI-ALPS index may serve as a potential biomarker for cognitive impairment in patients with WMHs.

Topics & Keywords

Cerebrospinal fluid and hydrocephalus Spinal Dysraphism and Malformations Advanced Neuroimaging Techniques and Applications

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: IBRO Neuroscience Reports

Volume 20, pp. 465-473

DOI: 10.1016/j.ibneur.2026.03.008

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