Spatial transcriptomic profiling reveals body site-specific inflammatory differences in psoriasis lesions

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Authors

Thomas Emmanuel · Aarhus University Hospital

Hakim Ben Abdallah · Aarhus University Hospital

Morten Muhlig Nielsen · Aarhus University Hospital

B. Ignatov · University of Copenhagen

Elena Baez · Aarhus University Hospital

Anna Skarnvad Andersen · Aarhus University Hospital

Line Waaben

Abstract

These findings highlight minimal histological and immunohistochemical variation, yet significant transcriptomic and pathway differences between psoriasis body locations, suggesting potential targets for site-specific therapeutic strategies.

Topics & Keywords

Psoriasis: Treatment and Pathogenesis Spondyloarthritis Studies and Treatments Dermatology and Skin Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 17, pp. 1706701-1706701

DOI: 10.3389/fimmu.2026.1706701

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