CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective, multicenter initiative integrating high‐resolution multi‐omics (transcriptomics, proteomics, metabolomics, and scRNA‐Req) with deep clinical phenotyping. By combining molecular trajectories with continuous vital signs and laboratory data, CMAISE provides an unprecedented resource to decode sepsis complexity. This correspondence outlines the cohort design, data resources, and its potential to accelerate the discovery of treatable traits.