Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer

20260 citationsJournal Articlegold Open Access

Authors

Severien Van Keer · Infectious Diseases Institute

Rianne van den Helder · Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital

Laura Téblick · Infectious Diseases Institute

Annemie De Smet · Infectious Diseases Institute

Gilbert Donders · Antwerp University Hospital

Steven Weyers · Ghent University Hospital

Jean Doyen

Abstract

The ASCL1/LHX8 methylation test detects nearly all cancers and a majority of CIN3 in first-void urine, supporting the potential of full molecular screening in urine by primary HPV testing and methylation triage.

Topics & Keywords

Cervical Cancer and HPV Research Epigenetics and DNA Methylation Endometrial and Cervical Cancer Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Communications Medicine

DOI: 10.1038/s43856-026-01512-x

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