Strategic Governance of Artificial Intelligence–Enabled Clinical Algorithm Development: Formative Evaluation of the Semiautomatic Clinical Algorithm Development Framework

These preliminary findings suggest that the S-ACAD framework may offer a potential pathway for "active governance" in AI-assisted clinical content development. In this proof-of-concept case, the framework combined rapid AI-assisted drafting with continuous expert oversight and independent clinical review, suggesting the potential to reduce turnaround time while maintaining safety safeguards. However, these results are based on a single expert applying the workflow to a single clinical topic, and validation across multiple experts, topics, and institutional contexts is needed before generalizability can be established.