Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma

20260 citationsJournal Articlegold Open Access

Authors

Junyi Zhang · University of Freiburg

Jasmin von Ehr · University of Freiburg

Thomas Look · University of Zurich

Jasim Kada Benotmane · University of Freiburg

Nicolas Neidert · University of Freiburg

Jan Kueckelhaus · University of Freiburg

Tobias Weiss ·

Abstract

These data map the microenvironmental and transcriptional changes associated with rapid CAR-T cell dysfunction in GB and identify candidate pathways and regulators that may be leveraged to engineer more durable cellular therapies.

Topics & Keywords

CAR-T cell therapy research Immune Cell Function and Interaction Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: BMC Medicine

DOI: 10.1186/s12916-026-04783-2

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