Preventive Rotavirus Vaccination in a Defined Region: Implementation Under the Regional Immunization Schedule

Relevance. Rotavirus infection remains epidemiologically and economically significant to this day. Aim. To evaluate the preventive effectiveness of the rotavirus vaccine in the vaccination of young children. Materials and methods. This article presents a comparative analysis of rotavirus enteritis incidence across different age groups in the municipal district of «Berezniki City» during the pre-mass vaccination (2010–2018) and mass vaccination (2019–2024) periods. The comparison region was the Kudymkarsky Municipal District, where rotavirus immunization was not implemented. Results and discussion. The findings demonstrate a significant decrease in rotavirus enteritis incidence among residents of the «Berezniki City» municipal district during the mass vaccination period compared to the pre-vaccination era, confirming the high preventive efficacy of rotavirus enteritis immunization. Conclusion. The obtained data support the necessity of introducing mass vaccination against rotavirus infection in first-year infants within specific regions as the most effective tool for reducing morbidity and improving the epidemiological situation.