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Open-source and commercial fifth-generation (5G) deployments are difficult to compare because they are built for different goals and reported under different conditions, which slows down validation and technology transfer from research to practice. This study explores the deployment and evaluation of two 5G Standalone (SA) disaggregated Radio Access Network (RAN) systems, using open-source research RAN, commercial RAN, and Software-Defined Radio (SDR) hardware. The first testbed is a SDR-based prototype, containing a Universal Software Radio Peripheral (USRP) B210 device, using Software Radio System RAN (srsRAN) as the RAN. The commercial-based testbed contains a Benetel RAN550 Radio Unit (RU), connected via an optical fiber to a Commercial Off-the-Shelf (COTS) server acting as the Distributed Unit (DU) and Centralized Unit (CU) using the Accelleran virtualized Baseband Unit (vBBU) platform. The Core Network (CN) is implemented using the open-source Open5GS in both testbeds. To evaluate the network’s functionality, throughput and latency are tracked using a Motorola Edge 50 Pro mobile terminal. The experimental results are analyzed and compared with representative performance metrics reported in the literature to place the measurements in a broader research context. This study further assesses trade-offs related to cost, portability, and scalability by comparing SDR-based research prototypes with commercial deployments.