Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

20260 citationsJournal Articlehybrid Open Access

Authors

Luz Andrea Martínez‐Pérez · Universidad de Guadalajara

M. Ujue Latasa · Navarre Institute of Health Research

Iker Uriarte · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Amaya López‐Pascual · Navarre Institute of Health Research

Jasmin Elurbide · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Pavel Strnad · Universitätsklinikum Aachen

Abstract

TFF3 is a hypoxia-inducible factor that enhances HB cell proliferation, survival and chemoresistance. Its tumour-promoting activity through C-MYC and mTOR pathways identifies TFF3 as a potential therapeutic target and circulating biomarker in hepatoblastoma.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Microbial metabolism and enzyme function Tuberous Sclerosis Complex Research

Publication Details

Published in: Liver International

Volume 46, Issue 4, pp. e70592-e70592

DOI: 10.1111/liv.70592

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Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

Authors

Abstract

Topics & Keywords

Publication Details