Nucleolar Targeting by Oropouche Virus Nonstructural Protein Mediates RNA Polymerase II Degradation and Interferon Antagonism

OROV NSs suppresses host transcription via nucleolar targeting and RNAPII degradation and partially modulates IFN-I signaling downstream of IFNAR activation, representing an evolutionarily acquired immune evasion mechanism. These findings enhance our understanding of OROV pathogenesis and help to identify NSs as a potential antiviral target.