The Effect of Pharmaceutical Excipients on Protein Chemical Degradation Through Deamidation and Isomerization

20260 citationsJournal Articlehybrid Open Access

Authors

Ingrid Ramm · Lund University

Carl Diehl · SARomics Biostructures (Sweden)

Amanda Västberg · Lund University

Johanna Hjalte · Lund University

Herje Schagerlöf · Lund University

Marie Wahlgren · Lund University

Lars Nilsson · Lund University

Abstract

These results demonstrate how excipient-induced structural changes affect chemical degradation of proteins in liquid formulations. This study contributes to the understanding and design of more effective formulations for therapeutic proteins, enhancing their stability and safety.

Topics & Keywords

Protein purification and stability Advanced Glycation End Products research Protein Interaction Studies and Fluorescence Analysis

Publication Details

Published in: Pharmaceutical Research

DOI: 10.1007/s11095-026-04040-4

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The Effect of Pharmaceutical Excipients on Protein Chemical Degradation Through Deamidation and Isomerization

Authors

Abstract

Topics & Keywords

Publication Details