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Aim. The aim of the study was to study the effect of first appeared persistent left bundle branch block on the prognosis of patients after «MedLab-CT» transcatheter aortic valve implantation (TAVI) in the middle long-term follow-up period. Methods. The study included 129 patients after the TAVI procedure, who initially did not have LBBB. The average age of patients was 70.2±5.2 years, body mass index - 31.4±5.9 kg/m2, the proportion of men was 36%, arterial hypertension was diagnosed in 93%, diabetes mellitus in 32%, coronary heart disease in 59% of patients, paroxysmal form of atrial fibrillation was registered in 16%, permanent form of atrial fibrillation - in 3% of patients. According to echocardiography the end-diastolic volume was 107.7±30.9 ml, the ejection fraction was 61.4±10.4%, the maximum and average pressure gradient on the aortic valve was 91.7±25.7 mmHg and 52.7±16.4 mmHg respectively. The width of the QRS complex was 84.1±12ms. Depending on the occurrence of LBBB after the TAVI procedure, the patients were divided into 2 groups: the first group included 98 patients without LBBB (the width of the QRS complex was 98.4±16ms), the second included 31 patients with LBBB (the width of the QRS complex was 149.6±17ms). The groups were comparable in other clinical, demographic and ultrasound parameters. The follow-up period was 60 months. Results. There were no differences in echocardiography data in both groups, and mortality rates from all causes were also comparable. During the follow-up period in the LBBB group two patients was implanted a pacemaker (6.45%; p=0.001). The LBBB after TAVI did not increase all-cause mortality in patients (OR 1.084; DI= 0.353-3.209; p=0.912). Conclusion. The first time arisen LBBB does not increase mortality in patients after TAVI «MedLab-CT» in the middle long-term follow-up period, but it is associated with a higher risk of developing a high-grade atrioventricular block requiring pacemaker implantation.