The MTH1 inhibitor TH287 sensitized Castration-Resistant Prostate Cancer cells to ionizing radiation therapy

20260 citationsJournal Articlehybrid Open Access

Authors

Xingbang Hu · The Second Affiliated Hospital of Bengbu Medical College

Zhizhong Tang · Gaozhou People's Hospital

Abstract

Overall, TH287 exhibited potent radiosensitization effects for CRPC treatment, effectively killing tumor cells when administered alongside IR at 12 h after the initial drug treatment.

Topics & Keywords

Prostate Cancer Treatment and Research Estrogen and related hormone effects TGF-β signaling in diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Urology and Nephrology

DOI: 10.1007/s11255-026-05096-2

Field-Weighted Citation Impact: 0.00