(O-18) Sexual Dysfunction Among Female Patients with Solvent Exposure

Abstract Background Normal female sexual function may be influenced by various exogenous factors such as age, ovarian reserve, hormonal imbalances, and environmental chemicals. Exposure to hazardous substances, particularly solvents, and psychosocial risks in occupational settings has increased among female workers. However, little research has been conducted in Tunisia on the impact of solvent exposure on women’s sexual health. This study aims to evaluate the sexual and psychological impact of solvent exposure among Tunisian women. Methods We conducted a prospective longitudinal study on five female patients who consulted the occupational health and security department between 2017 and 2024 for neuropsychiatric symptoms and were diagnosed with solvent psycho-syndrome. They were contacted by phone in January 2025 for follow-up. Three validated scales were administered: Health literacy scale -Questions 16, Hospital anxiety and depression scale, and female sexual function index. Results The study included five Tunisian women with a mean age of 34 years (±SD 5.98). All participants reported an active sexual life and identified as heterosexual. The median duration of solvent exposure was 11.2 years (range: 9–13 years). Occupational roles included exposure to welding fumes, glue, methanol, toluene, cyclohexanone, xylene, paint strippers, and cleaning solvents. Only two participants ceased solvent exposure after resigning, while three continued to be exposed. The median Health Literacy Scale score was 7 (range: 1–13). Three women exhibited moderate depression, and two reported moderate anxiety. The mean FSFI score was 13.5 (±SD 1.89), with notable impairments in sexual desire, arousal, lubrication, orgasm, and satisfaction. Our study highlights the link between chronic solvent exposure and sexual dysfunction among female workers. Our study revealed that three of the five participants exhibited moderate depression, while two reported moderate anxiety, highlighting the interplay between psychological distress and sexual dysfunction. Additionally, occupational exposure to solvents is often accompanied by psychosocial stressors, including economic instability, work-related stress, and limited access to healthcare. Conclusion Sexual dysfunction is a significant but often overlooked consequence of chronic solvent exposure in occupational settings. Our study emphasizes the importance of routine sexual health assessments among exposed workers. Individual and collective protection equipment are necessary to reduce workers ‘exposure and the impact of solvent exposure on sexual and mental well-being.