Histological signatures of hormone replacement therapy in the endometrium

In this retrospective case series, no endometrial hyperplasia or cancer was identified among 24 women with documented HRT status. However, the study was severely underpowered to detect rare but clinically significant pathologies. The absence of abnormal findings likely reflects the small sample size and low baseline incidence, rather than a protective effect. The high rate of missing HRT documentation (61.3%) represents a significant quality gap. These findings underscore the limitations of small retrospective series and highlight the need for adequately powered, prospective studies with systematic HRT characterization.