Group 4 Medulloblastomas of Early Childhood Treated With High‐Dose Chemotherapy‐ and Craniospinal Irradiation‐Sparing Approach

High dose chemotherapy for Group 4 MB was associated with a relapse rate of 52.6%, which favorably compares to data reported with conventional chemotherapy. Salvage radiotherapy retrieved more than two-thirds of the patients. Half of the survivors never received radiotherapy. Such an approach may represent an alternative to upfront CSI for young children with Group 4 MB.