To Evaluate the Efficacy of Pathadya Churna in the Management of Grahani Dosha - A Clinical Trial

Background: In Ayurveda, Grahani Dosha refers to a functional disorder of the gastrointestinal system, primarily linked with disturbances in Agni and formation of Aam. So, the biological fire responsible for digestion, absorption, and metabolism. These clinical features show close resemblance to irritable bowel syndrome (IBS) described in contemporary medical science. Pathadya Churna is mentioned in the Chakradutt classics for the treatment of Grahani Dosha. Methods: Among 100 registered patients, 100 of them completed the course of treatment. They were administered. with Pathadya Churna (3g) twice daily after food with Madhu as Anupana (adjuvant) for a period of 30 days. Wilcoxon matched-pairs sign rank test was used to analyze the significance of change in pre-and post-treatment changes in subjective parameters, Agni, and Aam parameters. WHO-QOL domain scores (all eight domains) were evaluated using both the paired t-test and the Wilcoxon matched-pairs signed Rank test. Result: There was Significant Improvement in the Primary and secondary Outcomes Measures of Grahani Dosha. Conclusion: Pathadya Churna is effective in the management of Grahani Dosha.