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Homeopathic practice is founded on individualisation and the totality of symptoms, seeking correspondence between a patient's clinical manifestations and the effects observed in drug provings. This conceptual basis demands research strategies that uphold contemporary standards of clinical science while ensuring model validity, faithfully representing the therapeutic rationale of homeopathy. The choice of an appropriate methodological design is essential to ensure both reliability and consistency with homeopathic principles. Conventional frameworks such as randomised controlled trials must be adapted to preserve model validity, particularly through the use of individualised prescriptions. In other contexts, research may employ standardised remedies (including the <i>genus epidemicus</i>), N-of-1 trials, non-randomised interventional studies or observational designs. The suitability of each model depends on clinical characteristics (chronic, acute or epidemic conditions), the purpose of the study (exploratory or confirmatory), epidemiological factors such as symptom homogeneity, morbidity and mortality, as well as statistical considerations. This article thus examines the theoretical, clinical, and epidemiological criteria guiding the selection of research designs in homeopathy. By emphasising model validity as a central criterion, and by analysing the conceptual foundations, practical challenges and limitations of each approach, it aims to promote the methodological and clinical relevance of homeopathy research.