Dengue molecular dynamics: viral load and serotype shifts predict severity and death in Kolkata, Eastern India

20260 citationsJournal Article

Authors

Suman Kundu · ESI - Post Graduate Institute of Medical Science and Research

Swagata Ganguly Bhattacharjee · Nil Ratan Sircar Medical College and Hospital

Arup Kumar Pattanayak · Nil Ratan Sircar Medical College and Hospital

Indira Dey · Nil Ratan Sircar Medical College and Hospital

Dipankar Maji · Salt Lake Regional Medical Center

Kaushik Pramanik · Nil Ratan Sircar Medical College and Hospital

Abstract

The study identifies a 'prevalence-virulence dissociation' where DENV-2 dominates numerically but DENV-3 drives mortality. Quantitative viral load is a robust prognostic marker. Integrating real-time molecular surveillance and Ct threshold into triage protocols is vital for mitigating fatal outcomes in hyperendemic regions.

Topics & Keywords

Mosquito-borne diseases and control Malaria Research and Control Dengue and Mosquito Control Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene

DOI: 10.1093/trstmh/trag027

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