DNA Methylation Profiling Reveals a Novel Subtype Harboring IDH Mutation in H3-altered Gliomas

20260 citationsJournal Article

Authors

Min Fu · Fudan University

Yuan Feng · Fudan University

Pin Sun · Fudan University

Ming You · Fudan University

Licheng Zhang · Fudan University

Hui Yang · Wannan Medical College

Yi Zhang · Fudan University

Abstract

Our study redefines H3-altered gliomas through methylation-based taxonomy, identifies a novel IDH/H3_comut subtype with favorable prognosis, and reveals subtype-specific therapeutic vulnerabilities, including potential responsiveness to hypomethylating agents or CDK4/6 inhibitors.

Topics & Keywords

Glioma Diagnosis and Treatment Chromatin Remodeling and Cancer Neuroinflammation and Neurodegeneration Mechanisms

Publication Details

Published in: Neuro-Oncology

DOI: 10.1093/neuonc/noag054

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DNA Methylation Profiling Reveals a Novel Subtype Harboring IDH Mutation in H3-altered Gliomas

Authors

Abstract

Topics & Keywords

Publication Details