Impact of micronutrients on the effects of anticonvulsant drugs in the experiment

Background : In recent years, there has been an intensive search for anticonvulsants with fewer adverse effects. the study of micronutrients that can potentiate the action of anticonvulsants, and in particular myoinositol (vitamin B 8 ), seems promising. Methods: an experimental study of the neurotropic and anticonvulsant effects of a myoinositol-based drug was conducted using a thiosemicarbazide seizure model. the study was conducted on male rats. the animals were divided into groups pre-treated with the anticonvulsants sodium valproate and gabapentin, and in combination with myoinositol and folic acid. In the experimental groups, the seizure model was simulated by administering the convulsant. Myoinositol levels in the blood plasma of the experimental animals were determined. Results: a course of administration of an inositol-containing preparation to a thiosemicarbazide-induced seizure model significantly increased the latency to the first seizure, reduced seizure severity (p <0.05), and decreased mortality. an enhanced anticonvulsant effect of sodium valproate and gabapentin was observed, and the neuroprotective effect of myoinositol preparations was confirmed. administration of anticonvulsants resulted in a significant decrease in plasma inositol concentrations. a course of administration of an inositol-containing preparation maintained and significantly increased plasma inositol concentrations in animals treated with the anticonvulsants gabapentin and sodium valproate. Conclusion : a drug containing myoinositol and folic acid modulates the effects of drugs with both convulsant and anticonvulsant effects.