NETosis-derived PADs mediate Citrullination of Oral Bacteria to promote Inflammation in Rheumatoid Arthritis

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Authors

Suman Acharya · VA Palo Alto Health Care System

Camille Brewer · VA Palo Alto Health Care System

Alejandro M. Gomez · VA Palo Alto Health Care System

Shady Younis · VA Palo Alto Health Care System

Mahesh Pandit · VA Palo Alto Health Care System

Shaghayegh Jahanbani · VA Palo Alto Health Care System

Orr Sharpe

Abstract

Our data support the hypothesis that in RA patients with PD, citrullinated oral bacteria breach damaged periodontal tissue to enter the circulation and induce both innate and adaptive proinflammatory responses that promote synovial tissue destruction.

Topics & Keywords

Neutrophil, Myeloperoxidase and Oxidative Mechanisms Rheumatoid Arthritis Research and Therapies Oral microbiology and periodontitis research

Publication Details

Published in: The Journal of Rheumatology

DOI: 10.3899/jrheum.2025-0792

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NETosis-derived PADs mediate Citrullination of Oral Bacteria to promote Inflammation in Rheumatoid Arthritis

Authors

Abstract

Topics & Keywords

Publication Details