Excess fructose and palm oil in the diet as factors of the development of multiple organ pathology in the experiment

Background: the quantity and quality of food entering the human body are important factors affecting human health. Currently, the food industry is directed towards expanding the composition of components, including excess fats (palm oil) and carbohydrates (hidden sweeteners, primarily sucrose and high-fructose corn syrup), which can potentiate the development of metabolic-associated fatty liver disease, in which there is often a violation of the exchange of nutrients, including iron. Since the problem of an unbalanced diet, in which the share of palm oil and fructose is growing, is currently important, lowering their toxic effects with the help of a standardized human placenta hydrolyzate is very relevant, especially in patients with chronic liver diseases. Methods : the scientific study was performed on 24 rats. an experimental model of metabolic-associated fatty liver disease was reproduced, caused by a combined intake of excess palm oil, fructose and iron sulfate. Results: the results of the study show the effectiveness of human placenta hydrolysate in the treatment of metabolicassociated fatty liver disease, including cases with iron overload. after reproducing the model, there was a statistically significant increase in ferritin, aSt, alt, leukocytes, and platelets, and a decrease in total protein, creatinine, and glomerular filtration rate. after 30 days, the levels of ferritin, alt, leukocytes, and platelets significantly decreased in the animals that received human placenta hydrolysate, while the levels of total protein significantly increased, and the levels of creatinine and glomerular filtration rate normalized. the results of the pathomorphological study showed that human placenta hydrolysate enhances the excretion of iron from the liver and prevents damage to the kidneys, brain, and myocardium in the studied model of metabolic-associated fatty liver disease. Conclusion: the use of human placenta hydrolysate is effective in the treatment of experimental metabolic-associated fatty liver disease caused by the combined intake of excess palm oil, fructose, and iron sulfate.