Integrated Multi-Omics Analysis Reveals IRF1-Driven Microglial PANoptosis via ZBP1 in Spinal Cord Injury

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Authors

Xiongjie Xu · Fujian Medical University

Song Chen · Fujian Medical University

Shichao Liu · Fujian Medical University

Yinqing Wang · Fujian Medical University

Chunhua Wang · Fujian Medical University

Risheng Liang · Fujian Medical University

Abstract

These findings highlight the IRF1-ZBP1 axis as a regulatory mechanism of PANoptosis in microglia following SCI and suggest it as a potential therapeutic target to modulate neuroinflammation.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Spinal Cord Injury Research Inflammasome and immune disorders

Publication Details

Published in: Journal of Inflammation Research

Volume Volume 19, pp. 1-18

DOI: 10.2147/jir.s574990

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Integrated Multi-Omics Analysis Reveals IRF1-Driven Microglial PANoptosis via ZBP1 in Spinal Cord Injury

Authors

Abstract

Topics & Keywords

Publication Details