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The possibility of realizing Higgs inflation in a model with a small non-minimal coupling constant, which was demonstrated recently, provides grounds for further development of the model. Incorporating the electroweak SM into the Two-Measure theory (TMT) in a way that fully accounts for the TMT structure leads to a theory we call the Two-Measure Standard Model (TMSM). The TMSM is realized in the context of cosmology as a set of cosmologically modified copies of the Glashow–Weinberg–Salam (GWS) theory, such that each of the copies exists as a local quantum field theory defined on the classical cosmological background at the appropriate stage of its evolution. This basic idea is studied in detail for two stages of the cosmological background evolution: for slow-roll inflation and for the stage of approaching the vacuum. Mainly due to the presence of the ratio of two volume measures in all equations of motion, all TMSM coupling constants turn into a kind of “running” (classical) TMT-effective parameters. During the evolution of the cosmological background, changing these parameters yields new results: (1) the classical “running” TMT-effective Higgs self-coupling parameter increases from λ∼10−11 (which provides Higgs inflation consistent with the Planck CMB data at ξ=16) to λ∼0.1 at the stage close to the vacuum; (2) the mass term in the TMT-effective Higgs potential changes sign from positive to negative, which provides SSB in the standard way of GWS theory; (3) the classical “running” parameters of the gauge and Yukawa couplings change by several orders of magnitude; (4) the GWS theory is reproduced when the Yukawa constant in the original action is chosen to be universal for three generations of fermions. We show that, due to these classical-level results, taking into account quantum corrections in the one-loop approximation preserves the slow-roll inflation regime and does not violate the vacuum stability during inflation.