Phenotypic and genotypic characterization of Plasmodium falciparum field isolates lacking pfhrp2 gene

P. falciparum Peruvian field isolates with pfhrp2 positive pattern showed cytoadherence to Chondroitin sulfate A protein (R-, CS + , Hu-) or positive characteristics for rosetting (R + , CS-, Hu-); pfhrp2 negative parasites showed cytoadherence to HUVEC cells (R-, CS-, Hu +). In this small set of Peruvian field isolates, a clear cytoadherence and resolution profile was observed for the different pfhrp2 patterns. These findings should be interpreted as preliminary and require further verification in larger isolated panels.