From Crisis to Control: A Study of Typhoid Conjugate Vaccine Efficacy in Harare, Zimbabwe (2017–2024)

TCV reduced typhoid incidence, particularly in high-burden areas and children. No shift in the <i>Salmonella</i> Typhi population was observed. Ongoing transmission underscores need for integrated measures, including human-resource capacity, improved water, sanitation, and hygiene infrastructure, research on vaccine performance variability, and refined multisectoral interventions.