Weight Regain Reverses Caloric Restriction–Induced Benefits on the Insulin–IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial

20260 citationsJournal Article

Authors

Moritz V. Warmbrunn · The University of Sydney

Lin Yang · Alberta Health Services

Raaj Kishore Biswas · The University of Sydney

Calen P. Ryan · Columbia University

Amy Harper · Alberta Health Services

Daniel W. Belsky · Columbia University

Giovanni Fiorito ·

Abstract

Substantial weight loss followed by weight regain can attenuate or reverse CR-induced benefits on key regulators of the insulin-IGF-1 nutrient-sensing pathway and markers of biological aging. Sustained, moderate weight loss more effectively improves insulin resistance and maintains favorable hormonal profiles linked to type 2 diabetes risk and aging biology.

Topics & Keywords

Genetics, Aging, and Longevity in Model Organisms Growth Hormone and Insulin-like Growth Factors Regulation of Appetite and Obesity

Publication Details

Published in: Diabetes Care

DOI: 10.2337/dc25-1911

Field-Weighted Citation Impact: 0.00

Command Palette

Weight Regain Reverses Caloric Restriction–Induced Benefits on the Insulin–IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial

Authors

Abstract

Topics & Keywords

Publication Details