Autophagy is essential for anti-Wolbachia drug efficacy in Brugia malayi and insect cells

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Authors

Anfal Yousef · Liverpool School of Tropical Medicine

Ellen K. G. Masters · Liverpool School of Tropical Medicine

Yang Wu · Liverpool School of Tropical Medicine

W. David Hong · Robert Morris University

Paul M. O’Neill · Robert Morris University

Joseph D. Turner · Liverpool School of Tropical Medicine

Steve A. Ward

Abstract

These results demonstrate the critical role of host autophagy in anti-wolbachia drug activity and a previously unrecognised host-directed mechanism in insect cells and <i>B. malayi</i>.

Topics & Keywords

Parasitic Diseases Research and Treatment Lysosomal Storage Disorders Research Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Microbiology

Volume 17, pp. 1771755-1771755

DOI: 10.3389/fmicb.2026.1771755

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