Evaluation of Organic- Versus Synthetic-Derived Multivitamin and Mineral Supplementation on Circulatory Concentration in Healthy Humans: A Single-Blinded Randomized Intervention Study

Background: Growing consumer interest in organic products has stimulated demand for organically sourced multivitamins and minerals (MVM); however, evidence comparing their efficacy with conventional synthetic formulations is limited.Objective: This study aims to assess circulatory levels of organically sourced (ORG) versus synthetically produced (SYN) MVM supplements.Methods: Single-blind randomised 30-day intervention, in which healthy adults (n=62) ingested either ORG or SYN-sourced MVM formulations.Circulating MVM concentrations assessed at baseline and post-intervention.A subset of participants (n=19) completed an acute crossover trial for assessment 2-hour post-ingestion.Results: Both ORG and SYN produced comparable changes in circulating micronutrient levels across 2-hour and 30-day ingestion protocols, with no significant changes between groups for all vitamins and minerals.Over 30-day ingestion resulted in significant within group changes; elevated Biotin concentrations over time (F=5.36,p=0.022), and B9 folate (F=5.46,p=0.021), in both the ORG (p<0.05) and SYN groups (p<0.05).No changes were observed for; Vitamin B12, Vitamin C, Vitamin D, Calcium, Zinc, Iron, Ferritin and Transferrin levels.2-hour ingestion resulted in significant increases in Vitamin B12, Vitamin D, Calcium, Zinc, Iron, and Ferritin for both supplement types, however elevated Folate and Transferrin were present in ORG only (both p<0.01).Conclusion: Organic and synthetic MVM formulations demonstrated similar post-ingestion circulatory profiles.These findings support the use of organic MVMs as functionally comparable alternatives to synthetically-sourced supplements, aligning with increasing consumer demand for organic, naturally derived health products.