Physical exercise as a catalyst for neuroimmune balance in schizophrenia: Targeting the kynurenine pathway in the PsyLetics project

This pilot study suggests that exercise can modulate kynurenine metabolism in schizophrenia, with picolinic acid emerging as a potential marker of clinical improvement. Psychosocial and fitness gains support exercise as a feasible adjunctive intervention, warranting larger studies to clarify underlying mechanisms within the kynurenine pathway.