Magnetic Polymeric Scaffolds for the Mechanotransduction Stimulation in Tendon Tissue Regeneration

Tendon injuries represent a health issue that annually affects millions of individuals. An innovative approach for the treatment is represented by tissue engineered scaffolds that support the host cells adhesion, differentiation, and proliferation. Magnetite nanoparticles (Fe3O4 NPs) combined with bio-mimetic scaffolds, should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation. With the TEN4CARE project (Horizon) we aim to develop shape memory biomaterials based on polymeric scaffold with magnetic nanoparticles. In this perspective with this proposal, we aim to characterize the new scaffolds based on polyurethane to test the effect of magnetic NPs on their structure. The structure of hydrated magnetic scaffolds will be observed as a function of tension to investigate the mechanical properties on the macro and nano scale.