A Pilot, Dose-Finding, Pharmacodynamic and Pharmacokinetic Study of Orally Administered Botanical Kratom

20260 citationsJournal Article

Authors

Chad J. Reissig · United States Food and Drug Administration

Ling Chen · United States Food and Drug Administration

Srikanth C. Nallani · United States Food and Drug Administration

E. Gregory Hawkins · United States Food and Drug Administration

Steven Galati · United States Food and Drug Administration

Katherine R. Bonson · United States Food and Drug Administration

Siva Rama Raju Kanumuri

Abstract

This study investigated the safety of single-sourced botanical kratom; the results may not be representative of other kratom-containing products. Kratom produced some opioid-like effects including pupillary constriction, and the 12 g dose produced effects commonly associated with drugs of abuse such as visual analog scale (VAS) ratings of drug liking, good effects, and high.

Topics & Keywords

Alkaloids: synthesis and pharmacology Berberine and alkaloids research Traditional and Medicinal Uses of Annonaceae

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Psychopharmacology

DOI: 10.1097/jcp.0000000000002158

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