Metformin Use and Development of Esophageal Squamous Cell Carcinoma

20260 citationsJournal Articlegold Open Access

Authors

Shao-Hua Xie · Karolinska University Hospital

Giola B. Santoni · Karolinska University Hospital

Helgi Birgisson · Icelandic Cancer Society

My Catarina von Euler-Chelpin · University of Copenhagen

Joonas H. Kauppila · Karolinska University Hospital

Eivind Ness-Jensen · Karolinska University Hospital

Jesper Lagergren

Abstract

In this case-control study, metformin use was associated with substantially lower odds of ESCC. This finding should prompt investigations of metformin as a preventive option in high-risk individuals and as a potential future therapeutic agent for ESCC.

Topics & Keywords

Metabolism, Diabetes, and Cancer Cancer Risks and Factors Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Network Open

Volume 9, Issue 3, pp. e262027-e262027

DOI: 10.1001/jamanetworkopen.2026.2027

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