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Abstract Creating a People-Centered Organization: 12 Organizational Actions to Reduce Burnout and Foster Professional Fulfillment tells the story of the evolving journey to create a better work environment for health care professionals. It dwells not on the story of occupational distress, burnout, moral injury, and cognitive dissonance but rather on a narrative of hope, well-being, camaraderie, values alignment, and meaning. Achieving this aspiration requires health care professionals and operational leaders working together to create 10 “Ideal Work Elements”: community at work and camaraderie; intrinsic motivation and rewards; control and flexibility; fairness and equity; professional development and mentorship; partnership; safety; trust and respect; gratitude; and work–life Integration. The ultimate aspiration is a people-centered organization with a culture that inspires enthusiasm, loyalty, engagement, and strong regard for the welfare of the team and the best interests of patients. Creating a People-Centered Organization: 12 Organizational Actions to Reduce Burnout and Foster Professional Fulfillment provides a road map for you to create such an environment for your team and organization. The map is paved with information about reliable, thoughtfully designed systems built on a psychologically safe and just culture. The authors drew on their extensive research on the well-being of health care professionals and their executive leadership experience in staff wellness, quality improvement, organization development, and operations management.