Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ

20260 citationsJournal Articlegold Open Access

Authors

Ayman Abouzayed · Uppsala University

Hugo Olsson · KTH Royal Institute of Technology

Natalia Papadopoulos · Uppsala University

Bogdan Mitran · Uppsala University

Hemantha Mallapura · Uppsala University

Tahmida Akter · Uppsala University

Irina Velikyan ·

Abstract

DOTA-ATH022 is a novel dimerized version of ATH001, with significantly improved affinity towards PDGFRβ. Retention of radiolabeled DOTA-ATH022 in PDGFRβ-avid tissues and tumors was increased, however uptake in solid tumor tissue was not improved.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research HER2/EGFR in Cancer Research Radiopharmaceutical Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EJNMMI Radiopharmacy and Chemistry

DOI: 10.1186/s41181-026-00439-x

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