Single Saliva Sample Linezolid Dosing for Multidrug-Resistant Tuberculosis: A Population Pharmacokinetic Modelling of Plasma and Saliva

20260 citationsJournal Articlehybrid Open Access

Authors

Thị Thanh Huyền Nguyễn · The University of Sydney

Tri P. Nguyen · The University of Sydney

Anh Nguyen Thi Nguyen · The University of Sydney

Luong Dinh · Hanoi Lung Hospital

Hoa B. Nguyen · Hanoi Lung Hospital

Hoa D. Vu · Hanoi University of Pharmacy

Tram N. B. Nguyen ·

Abstract

The validated model enables reliable estimation of plasma AUC<sub>0-24</sub> using limited saliva samples. A single saliva sample (pre-dose or 2 h post-dose) can accurately predict plasma AUC<sub>0-24</sub>, supporting saliva-based TDM as a practical alternative to plasma-based monitoring of linezolid in MDR-TB.

Topics & Keywords

Tuberculosis Research and Epidemiology Antimicrobial Resistance in Staphylococcus Antibiotics Pharmacokinetics and Efficacy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacokinetics

DOI: 10.1007/s40262-026-01626-4

Field-Weighted Citation Impact: 0.00