Adesão medicamentosa e qualidade de vida de pacientes com tuberculose multirresistente

Background and Objectives: The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) is associated with challenges in treatment adherence and impacts on quality of life (QoL). This study aimed to evaluate medication adherence and QoL in patients with MDR-TB. Methods: A cross-sectional, descriptive, and quantitative study was conducted in Northeastern Brazil, following the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement. In total, 50 patients participated in interviews using a semi-structured instrument. Adherence was assessed using the Brief Medication Questionnaire (BMQ). QoL was measured using the World Health Organization Quality of Life (WHOQOL-BREF). Results: Most participants were male (56%), 18–45 years old (60%), Black (86%), single (58%), with an income ≤1 minimum wage (98%), and incomplete high school (68%). According to the BMQ, 80% were adherent to treatment; 80% showed potential adherence to the regimen; 82% tested negative for belief barriers; and 92% tested negative for recall barriers. According to the WHOQOL-BREF, 50% considered their QoL to be fair. When considering the results by domain, the average scores ranged from 1.63 to 3.59. The social relationships domain had the lowest average (1.63±0.662), while the psychological domain had the highest average (3.59±0.958). Conclusion: High therapeutic adherence was demonstrated according to the BMQ criteria, contrasting with disparities in QoL, especially in the social relationships domain. The data reinforce the need for targeted psychosocial interventions to mitigate the identified gaps and ensure treatment Sustainability