.Xmp and .cmap files (raw data), .txt(processed summary result from .bnx, .xmap and .cmap) and .bw files (processed data) for detecting firing efficiency change when CENP-A overexpression

The .xmap and .cmap are mapping results of the DNA fiber in Bionano Based on raw data and mapping results, all the mapping DNA containing ongoing DNA replication labeled by dUTP are summarized in .txt files Based on .txt files to generate corresponding .bw(bigwig) files, whcih records the genome-wide DNA replication firing efficiency Then based on 0h S phase Wild Type and CENP-A overexpression(OE) .bw files to call DNA replication firing efficiency enriched and depleted regions by Hidden Markov Model we get Domains_oe/wt_State0/1.bed files. The state0 bed files will be recognized as DNA replication initiation zones(IZs). Then the common_IZ.bed is the overlapping between the OE(CENP-A overexpression) and WT(wild-type) IZs The Novel_IZ.bed records the OE(CENP-A overexpression) condition-specific IZs. The shuffle regions are the random regions along the genome with the same length and number of regions in Novel_IZ.bed as control group