Multidisciplinary Care of Patients With Penile Cancer

Penile squamous cell carcinoma (PSCC) is a rare malignancy that displays profound disparities in incidence, access to care, and clinical outcomes rooted in economic, social differences, and cultural practices. PSCC has been linked to high treatment-related morbidity, social stigma, and psychological distress. This chapter provides an overview of this disease, integrating epidemiology, pathology, imaging, and multimodal management strategies. The principles of penile cancer staging, histopathologic features, and the role of imaging in local staging of the primary tumor and nodal disease are also covered. As multimodal mkanagement has become increasingly central in penile, the role of inguinal lymph node dissection, sentinel lymph node biopsy, radiotherapy, and the current state of systemic therapies are also discussed. In addition, we discuss the growing roles of patient advocacy and psychosocial support, which are often overlooked, and highlights disparities in care and quality of life, as well as the importance of centralized cancer care. Advancing care in PSCC will require a concerted multidisciplinary effort and a pledge to patient-centered advocacy as well as global initiatives.