Modeling endometritis and the possibility of its new therapy

This article presents the results of studies modeling endometritis in rats using a single administration of bacterial lipopolysaccharide (LPS). The induced inflammatory process was accompanied by morphological changes, including leukocyte infiltration of the endoand myometrium, and decreased uterine tone and contractility. Systemic complex administration of antilysosomal drugs against the background of antibacterial and uterotonic therapy for 7 days caused a decrease in the intensity of the inflammatory process and the severity of neutrophilic infiltration of the endo- and myometrium, activation of the tone and contractile function of the uterus. A conclusion was made about the possibility of modeling acute endometritis in rats by a single intravaginal administration of LPS, as well as the high efficiency of a new method of treating endometritis using antilysosomal drugs (ovomin).